CONALT® Tyronium

Product Description

L-Tyrosine:
● L-Tyrosine supports the production of tyrosine, the precursor to thyroid hormones. This amino acid contributes to the synthesis of T3 and T4 hormones by the thyroid gland, thus regulating thyroid functions.
● L-Tyrosine helps balance low thyroid hormone levels in Hashimoto’s disease, supporting thyroid function and improving energy levels and overall well-being.
● L-Tyrosine is essential for the synthesis of T3 (triiodothyronine) and T4 (thyroxine) hormones, which regulate metabolic rate and energy production.
● L-Tyrosine supports the synthesis of catecholamines (dopamine, norepinephrine), which play a role in coping with stress, thereby reducing stress related to autoimmune diseases.
● L-Tyrosine contributes to balancing metabolic rate and energy production by supporting the production of thyroid hormones, which regulate the body’s energy utilization and fat burning.
● L-Tyrosine aids in the production of neurotransmitters such as dopamine and norepinephrine, which play a role in coping with stress, thereby contributing to hormonal balance.

Selenium (L-Selenomethionine):

• The patented Selenium Select® raw material delivers selenium in the purified L-selenomethionine form, ensuring excellent bioavailability and biological activity. L-selenomethionine, which is the form combined with the essential amino acid methionine, can be incorporated into protein synthesis within the body and also serves as a stored source of selenium. Selenium in this form provides a more prolonged and balanced biological effect, thereby particularly supporting thyroid functions, immune response, and metabolic processes.
• L-selenomethionine is a bioactive form of selenium that is easily absorbed by the human body. Selenium itself is an essential structural component of the deiodinase enzymes (DIO1, DIO2, and DIO3), which play a critical role in the healthy functioning of the thyroid gland by converting the prohormone thyroxine (T4) into its active form, triiodothyronine (T3). L-selenomethionine directly participates in the synthesis of these enzymes, thereby optimizing the production and activation of thyroid hormones. Notably, the Selenium Select® raw material standardization further enhances the bioavailability of selenium, supporting the balance of thyroid hormone metabolism. Studies have demonstrated that sufficient selenium intake assists in regulating the ratios of T4 and T3 (Ventura et al., 2017; Köhrle, 2005).
• Hashimoto’s thyroiditis is an autoimmune process characterized by the production of autoantibodies (anti-TPO, anti-Tg) against thyroid tissue by immune system cells. L-selenomethionine plays a crucial role in slowing the progression of Hashimoto’s by contributing to antioxidant defense mechanisms. As selenium is a cofactor of glutathione peroxidase (GPx), an enzyme present in high concentrations in the thyroid, it helps reduce oxidative stress and protects thyroid cells from free radical damage (Duntas et al., 2006). Moreover, scientific publications support that selenium supplementation can suppress the autoimmune process by lowering anti-TPO antibody levels (Göçmen et al., 2020). The high bioavailability of selenium in the Selenium Select® form helps reduce autoimmune responses in Hashimoto’s thyroiditis.
• During the production of thyroid hormones T4 and T3, thyroid cells generate substantial amounts of reactive oxygen species (ROS), which under normal circumstances can lead to harmful effects. L-selenomethionine enhances the activity of antioxidant enzymes such as glutathione peroxidase and thioredoxin reductase in thyroid cells, neutralizing these harmful ROS and ensuring healthier continuation of hormone production (Zimmermann & Köhrle, 2002). The Selenium Select® form, with its stabilized and highly pure L-selenomethionine content, further supports this protective effect.
• Selenium also plays a balancing role in the cytokine profile that regulates T-cell responses. When taken in the L-selenomethionine form, selenium suppresses the production of pro-inflammatory cytokines (e.g., TNF-α, IL-6), thereby softening the immune system’s aggressive behavior towards thyroid tissue (Rayman, 2012). It also supports the activity of regulatory T cells (Tregs), enhancing immune tolerance. Thus, L-selenomethionine in the Selenium Select® form helps mitigate immune responses that damage thyroid tissue in autoimmune conditions like Hashimoto’s.
• Thyroid hormones play a key role in regulating overall metabolic rate. Adequate selenium supplied through L-selenomethionine optimizes deiodinase activity, supporting T3 production. T3, at the cellular level, enhances mitochondrial biogenesis and increases basal metabolic rate. Furthermore, selenium’s antioxidant effects help maintain mitochondrial function and ensure more efficient energy production processes (Schomburg & Köhrle, 2008). The Selenium Select® standardization facilitates the sustainable and balanced continuation of these vital processes.
• Selenium is not only crucial for thyroid hormones but also for the general endocrine system. For instance, selenium has been shown to indirectly contribute to the synthesis of steroid hormones such as testosterone and estrogen (Wang et al., 2021). L-selenomethionine helps maintain cellular redox balance through the glutathione system, thereby laying the foundation for the proper functioning of hormone receptors. As a result, selenium in the Selenium Select® form plays a supportive role in balancing hormone levels and ensuring that hormones exert their intended effects in target tissues.